TARGETED THERAPY

 Targeted Therapy is a type of cancer treatment that utilizes drugs or other substances to accurately identify and attack particular types of malignant cells. This therapy can be used by itself or in combination with other treatments such as traditional or standard chemotherapy, surgery or radiation therapy.

Doctors keep a track of your skin changes and reduce doses accordingly. Most targeted therapies are either small molecules or monoclonal antibodies. Small-molecule compounds are typically developed for targets that are located inside the cell because these agents have relatively easy entry to cells. Monoclonal antibodies are comparatively bigger in size and are incapable of entering the cells, so they are often used only for targets outside the cells or on the cell surface. 

Targeted therapy works by first identifying a target in a candidate and then developing a therapy for that target in a way that it affects the target’s ability to promote cancer cell growth or survival.

Targeted therapies are now the focus of much anticancer drug development- they are the milestone of precision medicine, a form of medicine that uses a person’s genes and proteins to prevent, diagnose and treat life-threatening diseases.

What forms of targeted therapy are there?

Most targeted therapies are either small molecule drugs or monoclonal antibodies.

Small molecule drugs are used for intracellular targets because they are small enough to easily enter cells.

Monoclonal antibodies, also called therapeutic antibodies, are proteins made in a laboratory. These proteins are designed to attach to specific targets found on cancer cells. Some monoclonal antibodies mark cancer cells to improve their recognition and destruction by the immune system. Other monoclonal antibodies directly stop cancer cells from growing or cause cancer cells to self-destruct. In addition, some carry toxins to cancer cells. Learn more about monoclonal antibodies.

Who is it for? 

In some cancers, such as B. Chronic myelogenous leukemia (also known as CML). Most people with this cancer have a specific drug target and can be treated with that drug. However, it is often necessary to test tumors to see if they contain therapeutic targets.

Testing cancers for targets that may help guide treatment choices is called biomarker testing. For more information, see Cancer Treatment Biomarker Tests.

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